Copper(I) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand.
نویسندگان
چکیده
Copper(I) coordinating ligands in the Alzheimer's disease context have remained unexplored, despite the biological relevance of this redox state of the copper ion. Here, we show that the PTA ligand can remove copper from Aβ, prevent reactive oxygen species production and oligomer formation, two deleterious events in the disease's etiology.
منابع مشابه
Synthesis of Copper Nanoparticles in Aqueous Ambient Using Dismutation Reaction
The present study has investigated the synthesis of copper nanoparticles via copper dismutation reaction in an aqueous solution and ambient conditions. Copper (II) chloride hydrate ( ), sodium oleate (SO), sodium chloride (NaCl) and ethylene diamine (EN) have been used as copper (I, II) ions source, surfactant, chloride ions supplier and ligand, respectively. Also, an amount of hydrochloric aci...
متن کاملSynthesis, Characterization and Crystal Structure Determination of Copper (II) Complexes with 2,2′-Dimethyl-4,4′-bithiazole
Copper(II) complex [Cu(dmbt)2(H2O)](ClO4)2 (1) was prepared from the reaction of copper(II) perchlorate hexahydrate with 2,2'-dimethyl-4,4'-bithiazole (dmbt) ligand in methanol at ambient temperature. The complex was quantitatively and qualitatively characterized by elemental analysis, absorption and infrared spectrometries. Complex [Cu(DMSO)5](ClO4)2 (2) was also synt...
متن کاملGreen and efficient synthesis of propargylamines via A3 coupling reaction using a copper (II)–thioamide combination
A one pot green three‐component coupling reaction of aldehyde, phenylacetylene, and amine derivatives in the presence of copper (II)–thioamide combination as a novel and efficient heterogeneous catalyst under solvent–free conditions is reported. The catalyst displayed high activity and afforded the corresponding propargylamines in good to high yields. The key to this procedure was the generatio...
متن کاملSolid-phase Extraction Using Modified Carbon Nanotube and Cupferron Ligand for Preconcentration and Determination of Trace Amounts of Copper in Real Samples
A solid phase extraction procedure for simultaneous separation and preconcentration of traceamounts of Cu+2 ion from various real samples prior to its determination by flame atomicabsorption spectrometry has been developed. The proposed method is based on the utilization ofmultiwalled carbon nanotube in combination with Cupferron ligand as a solid phaseextractant. The influences of the analytic...
متن کاملP 59: Non-Steroidal Anti-Inflammatory Drugs as a Prevention of Alzheimer Disease: Risks and Benefits
Alzheimer's disease (AD) is a chronic neurodegenerative disease that accounts for 60 to 80 percent of all dementia cases. The exact cause of Alzheimer`s disease is still unknown, but recent studies suggest neuro-inflammation as an important part of the pathogenesis of the disease. This brings in mind using non-steroidal anti-inflammatory drugs (NSAID) as treatment or prevention of the disease. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Metallomics : integrated biometal science
دوره 7 8 شماره
صفحات -
تاریخ انتشار 2015